About the lab
Our laboratory is fully equipped with essential tools that will enable trainees to isolate and analyze novel genes as well as functionally characterize ion channels and associated proteins. We currently have several projects available for potential graduate students and post-doctoral fellows.
Research funding comes from a variety sources including the Natural Science and Engineering Research Council of Canada (NSERC), Canadian Foundation for Innovation, the Ontario Ministry of Research and Innovation and the University of Ontario Institute of Technology.
Publications (Pubmed Link)
Beech RN, Callanan M, V Rao, Dawe B and Forrester SG (2013) Characterization of cys-loop receptor genes involved in inhibitory amine neurotransmission in parasitic and free living nematodes. Parasitology International (In press)
Siddiqui S, Accardi MV, Brown DR and Forrester SG (2012) Hco-LGC-38 is a novel nematode GABA-gated chloride channel from Haemonchus contortus. Molecular and Biochemical Parasitology 185(2):137-44
Accardi MV, Beech RN and Forrester SG (2012) Nematode cys-loop GABA receptors: biological function, pharmacology and sites of action of anthelmintics. Invertebrate Neuroscience 12:3-12
Brown DR, Siddiqui SZ, Kaji M and Forrester SG (2012) Pharmacological characterization of the Haemonchus contortus GABA-gated chloride channel, Hco-UNC-49: modulation by macrocyclic lactone anthelmintics and a receptor for piperazine. Veterinary Parasitology 185: 201-209
Accardi MV and Forrester SG (2011) The Haemonchus contortus UNC-49B Subunit Possesses the Residues Required for GABA Sensitivity in Homomeric and Heteromeric Channels. Molecular and Biochemical Parasitology 178(1-2):15-22.
Vijayaraghava T Rao; Sean G. Forrester; Kathy Keller and Roger Prichard (2011) Localization of serotonin and dopamine in Haemonchus contortus. International Journal of Parasitology 41: 249-254.
Vijayaraghava T Rao; Mike Accardi; Salma Siddiqui; Robin Beech; Roger Prichard;
Sean G. Forrester (2010) Characterization of a novel tyramine-gated chloride channel from Haemonchus contortus. Molecular and Biochemical Parasitology 173:64-8.
Siddiqui SZ, Brown DR, Rao VTS, Forrester SG (2010) An UNC-49 GABA receptor subunit from the parasitic nematode Haemonchus contortus is associated with enhanced GABA sensitivity in nematode heteromeric channels. Journal of Neurochemistry 113,1113-1122
Beech RN, Levitt N, Cambos M, Zhou S and Forrester SG (2010) Association of ion-channel genotype and macrocyclic lactone sensitivity traits in Haemonchus contortus. Molecular and Biochemical Parasitology 171, 74-80
Rao V, Siddiqui SZ, Prichard RK and Forrester SG (2009) A dopamine-gated ion channel (HcGGR3*) from Haemonchus contortus is expressed in the cervical papillae and is associated with macrocyclic lactone resistance. Molecular and Biochemical Parasitology 166: 54-61
Forrester SG and Siddiqui SZ (2008) A novel member of the ligand-gated chloride channel gene family from Hemonchus contortus. Parasitology 135: 539-545
Forrester SG and Pearce EJ (2006) Immunobiology of Schistosomes. In: Parasitic Flatworms: Molecular Biology, Biochemistry, Immunology and Physiology. Eds AG Maule and NJ Marks. CAB International
Forrester SG, Warfel PW and Pearce EJ (2004) Tegument expression of a novel type II receptor serine/threonine kinase in Schistosoma mansoni. Molecular and Biochemical Parasitology 136: 149-156
Forrester SG, Beech RN and Prichard RK (2004) Agonist enhancement of macrocyclic lactone activity at a glutamate-gated chloride channel subunit from Haemonchus contortus. Biochemical Pharmacology 67: 1019-1024
Prichard RK, Forrester SG, Njue A, Feng X, Liu J and Beech RN (2003). Receptor mechanisms of antiparasitics. Veterinary Pharmacology and Therapeutics 26 (supp): 29-31
Forrester SG, Prichard RK, Dent JA and Beech RN (2003) Haemonchus contortus: HcGluCla expressed in Xenopus oocytes forms a glutamate-gated ion channel that is activated by ibotenate and the anti-parasitic drug ivermectin. Molecular and Biochemical Parasitology 129(1):115-121
Forrester SG, Prichard RK and Beech RN (2002) A glutamate-gated chloride channel subunit from Haemonchus contortus: expression in a mammalian cell line, ligand-binding and modulation of anthelmintic binding by glutamate. Biochemical Pharmacology 63(6):1061-8
Forrester SG, Hamdan FF, Prichard RK and Beech RN (1999) Cloning, sequencing, and developmental expression levels of a novel glutamate-gated chloride channel homologue in the parasitic nematode Haemonchus contortus. Biochemical and Biophysical Research Communications 254: 529-534 doi:10.1006/bbrc.1998.0106
Forrester SG and Lankester MW (1998) Over-winter survival of first-stage larvae of Parelaphostrongylus tenuis (Nematoda: Protostrongylidae). Canadian Journal of Zoology 76: 704-710
Forrester SG and Lankester MW (1997) Extracting Protostrongylus spp. larvae from bighorn sheep feces. Journal of Wildlife Diseases 33: 868-872
Forrester SG and Lankester MW (1997) Extracting protostrongylid nematode larvae from ungulate feces. Journal of Wildlife Diseases 33: 511-516